An advisory for ashfall - which can contaminate water supplies, kill vegetation and irritate the lungs - was in effect for the surrounding area overnight but has since been lifted.
"Based on past events, the early stages of a Mauna Loa eruption can be very dynamic and the location and advance of lava flows can change rapidly," the USGS said.
If the eruption migrates beyond the walls of the summit caldera, lava flows could "move rapidly downslope", it added.
According to the USGS, Mauna Loa has erupted 33 times since 1843. The previous eruption in 1984 sent lava flows within 5 miles of Hilo, the island's most populous town.
But the Big Island's population has more than doubled since 1980 to around 200,000 residents and Hawaii's civil defence agency has warned residents could face a "lava disaster".
"These lava flows rarely present a risk to life, but they can be extremely destructive to infrastructure," said Dr Jessica Johnson, a British volcano geophysicist who has worked at the Hawaiian Volcano Observatory.
She warned the lava flows posed a risk to Hilo and Kona, another major population centre, adding that the volcanic gasses could cause breathing problems for locals,
Mauna Loa is the world's largest active volcano. There are other larger volcanoes but these are classified as dormant, meaning they have not erupted for a long time, or extinct, meaning they are almost certain not to erupt in future.