Three newly discovered cells in orthopaedic cells appear to be a phosphate storage reservoir essential for life.

Phosphate is essential for life. Researchers now find a micro-structure within animal cells, like a phosphate storage bank, which helps to reconcile the nutritional level within cells and triggers the process of maintaining organizational survival in the event of a nutritional shortage. The researcher classifies this structure as a new type of cellular device, which is the basic structure of cells, such as cell nuclear, lip service and cell film, which performs the role of micro-organs. On 3 May, the study was published in Nature.

“This was the first time that phosphate storage structures were found in animal cells.” Rebekka Wild, a biologists of the French National Scientific Research Centre, who did not participate in the study.

Phosphate is important for cell growth in plants, bacteria and fermentary mothers, contributing to cell exchange and energy generation. Although phosphate is known to be essential in animal tissues and cells, there is little research to explore its specific functions.

Charles Xu, a genetician at the University of Rockefeller, United States, played a good role in regulating the intestinality of fruit. The orthopaedic organization is a useful model for studying how diseases affect human intestinal cells.

Xu and colleagues feed phosphate (PFA), which can inhibit the absorption of phosphorous by cells. When dialectic and imaging of cells from the walls in the orchards, they noted that the lack of phosphate resulted in a sharp increase in the number of cells. When Xu and colleagues feed phosphate 10 per cent less than the standard level, this rapid build-up of cells also shows that phosphate does have an impact on the number of cells.

In order to understand how phosphate is having such effects, Xu and the team examined whether low phosphate levels affect genetic expression. A gene similar to a phosphate beacons in mammals, known to them as PXo. Xu and colleagues found that when cells lack phosphate, PXo’s expression was weak. This reduction in genetic expression has led to excessive division of cells. However, when researchers adjust their genes to overexpress PXo protein, cell breaks down.

Researchers mark PXo protein with sticks and note that it is associated with a series of cytospheric structures in cells that do not seem to be relevant to any known cell.

Researchers carefully observed these mysterious structures and found that they had several membranes and that PXo protein transmitted phosphate in the membrane. Once entering unfamiliar cells, phosphate is converted into phosphate, the latter being a major component of the cell film.

Xu indicated that when fruit-bearing cells lack phosphate, cellular fragmentation and the release of stored phosphorus lipses into each cell showed that their function was similar to that of storage. This disintegration has triggered a cell mechanism called Cka, triggering a pressure signal and increasing the generation of new cells. This may be a method of maintaining stable levels of phosphate in the intestinal walls, as an increase in the number of cells can absorb more nutrition. “It would be useful to regenerate more healthy cells in biota.”

Wild said that these findings formed the basis for exploring the existence of similar phosphate storage cells in other animals, including human beings. She added that an in-depth study of the PXo protein structure could be useful in revealing how it transposed phosphate into cells.

Xu stated that the next step would be to examine how these cells containing phosphate interact with other cellulars and how their dynamics change over time. “This opened the door to studying many other issues.” He said (Ox)

Information on relevant papers: