Introduction: In the rapidly evolving landscape of decentralized finance (DeFi) and blockchain technology, seamless integration with Web3 applications has become increasingly essential. MetaMask, a popular browser extension, serves as a gateway to the world of Web3, enabling users to interact with decentralized applications (dApps) directly from their browsers. However, for users engaging with numerous dApps, manually handling MetaMask interactions can be cumbersome and time-consuming. In this article, we explore how to automate MetaMask interactions using Python and Selenium WebDriver, empowering users to streamline their Web3 experiences.