Follistatin is part of a natural metabolic pathway for regulating muscle, bone, and fat balance. Higher follistatin levels correlate with more muscle mass, higher bone density, and lower bodyfat. Follistatin is also a metabolic regulator: Higher follistatin levels mean a shift from oxidative phosphorylation to glycolosis, higher insulin sensitivity and sufficiency, improved cholesterol markers, and a reduction in chronic inflammation in all body tissues. Follistatin has been observed to improve human skin and hair quality.